Department of Psychology and Behavioural Sciences, Zhejiang University, Xixi Campus, Hang Zhou 310028, People's Republic of China.
Psychopharmacology (Berl). 2012 May;221(1):171-6. doi: 10.1007/s00213-011-2557-0. Epub 2011 Nov 25.
Drug-related cues can elicit approach responses in drug users. However, no relevant research has ever concerned heroin abusers. In the present study, we investigated whether the abstinent heroin abusers demonstrated special behavioural tendencies to approach or avoid the drug-related stimuli compared with neutral stimuli.
Twenty-two male abstinent heroin abusers (AH) and 20 healthy males (NC) were tested by a Pull/Push Task. Participants pulled (approach response) or pushed (avoidance response) a lever in response to the content of stimulus pictures (i.e. heroin-related versus neutral). The approach and avoidance scores were therefore calculated based on response times and directions to reflect their behavioural tendencies.
Relative to the NC individuals, the AH individuals demonstrated significantly heightened tendencies to approach ("pull") the heroin-related stimuli in comparison with the neutral stimuli, while their tendencies to avoid ("push") the heroin-related stimuli were marginally blunted, reflecting a special bias for AH individuals to behaviourally approach, and simultaneously resist to avoid, heroin-related cues.
背景:药物相关线索会引起药物使用者的趋近反应。然而,目前还没有任何相关研究涉及海洛因使用者。在本研究中,我们调查了与中性刺激相比,戒毒的海洛因使用者是否表现出特殊的趋近或回避药物相关刺激的行为倾向。
方法:采用推-拉任务对 22 名男性戒毒的海洛因使用者(AH)和 20 名健康男性(NC)进行测试。参与者根据刺激图片的内容(即与海洛因相关的图片与中性图片)拉动(趋近反应)或推动(回避反应)操纵杆。然后根据反应时间和方向计算趋近和回避得分,以反映他们的行为倾向。
结果与结论:与 NC 个体相比,AH 个体表现出明显更强的趋近(“拉”)与海洛因相关刺激的倾向,而其对海洛因相关刺激的回避(“推”)倾向则略有减弱,这反映了 AH 个体对海洛因相关线索的特殊行为趋近和同时抵抗回避的偏向。