Digestive Department, Hospital Universitario Miguel Servet (Miguel Servet University Hospital), Zaragoza.
Int J Gen Med. 2011;4:741-50. doi: 10.2147/IJGM.S17788. Epub 2011 Oct 31.
Iron is necessary for the normal development of multiple vital processes. Iron deficiency (ID) may be caused by several diseases, even by physiological situations that increase requirements for this mineral. One of its possible causes is a poor dietary iron intake, which is infrequent in developed countries, but quite common in developing areas. In these countries, dietary ID is highly prevalent and comprises a real public health problem and a challenge for health authorities. ID, with or without anemia, can cause important symptoms that are not only physical, but can also include a decreased intellectual performance. All this, together with a high prevalence, can even have negative implications for a community's economic and social development. Treatment consists of iron supplements. Prevention of ID obviously lies in increasing the dietary intake of iron, which can be difficult in developing countries. In these regions, foods with greater iron content are scarce, and attempts are made to compensate this by fortifying staple foods with iron. The effectiveness of this strategy is endorsed by multiple studies. On the other hand, in developed countries, ID with or without anemia is nearly always associated with diseases that trigger a negative balance between iron absorption and loss. Its management will be based on the treatment of underlying diseases, as well as on oral iron supplements, although these latter are limited by their tolerance and low potency, which on occasions may compel a change to intravenous administration. Iron deficiency has a series of peculiarities in pediatric patients, in the elderly, in pregnant women, and in patients with dietary restrictions, such as celiac disease.
铁对于多种重要生理过程的正常发育是必需的。铁缺乏症(ID)可能由多种疾病引起,甚至可能由增加对这种矿物质需求的生理情况引起。其可能的原因之一是饮食中铁的摄入量不足,这种情况在发达国家很少见,但在发展中国家却很常见。在这些国家,饮食性铁缺乏症非常普遍,是一个真正的公共卫生问题,也是卫生当局面临的挑战。无论是否伴有贫血,铁缺乏症都会引起重要的症状,这些症状不仅是身体上的,还可能包括智力表现下降。所有这些,加上高患病率,甚至可能对社区的经济和社会发展产生负面影响。治疗方法包括补充铁剂。铁缺乏症的预防显然在于增加铁的饮食摄入,这在发展中国家可能很困难。在这些地区,含铁量较高的食物稀缺,因此人们试图通过在主食中添加铁来进行补偿。多项研究证实了这种策略的有效性。另一方面,在发达国家,无论是否伴有贫血,铁缺乏症几乎总是与导致铁吸收和损失之间负平衡的疾病有关。其治疗将基于对基础疾病的治疗,以及口服铁补充剂,尽管这些补充剂的耐受性和效力较低,有时可能需要改为静脉给药。铁缺乏症在儿科患者、老年人、孕妇以及饮食受限的患者(如乳糜泻患者)中具有一系列特殊性。