School of Public Health, College of Public Health and Nutrition, Taipei Medical University, 250 Wu-Hsing Street, 11031 Taipei, Taiwan.
BMC Cancer. 2011 Nov 24;11:495. doi: 10.1186/1471-2407-11-495.
In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection.
From the claims data, we identified 1,958 patients with newly diagnosed breast cancer during the period 2000-2008. A randomly selected, age-matched cohort of 7,832 subjects without cancer was selected for comparison. Multivariable logistic regression models were constructed to calculate odds ratios of breast cancer associated with viral hepatitis after adjustment for age, residential area, occupation, urbanization, and income. The age-specific (<50 years and ≥50 years) risk of breast cancer was also evaluated.
There were no significant differences in the prevalence of hepatitis C virus (HCV) infection, hepatitis B virus (HBV), or the prevalence of combined HBC/HBV infection between breast cancer patients and control subjects (p = 0.48). Multivariable logistic regression analysis, however, revealed that age <50 years was associated with a 2-fold greater risk of developing breast cancer (OR = 2.03, 95% CI = 1.23-3.34).
HCV infection, but not HBV infection, appears to be associated with early onset risk of breast cancer in areas endemic for HCV and HBV. This finding needs to be replicated in further studies.
在台湾，乳腺癌的发病率较高，病毒性肝炎的患病率也较高。在这项病例对照研究中，我们使用基于人群的保险数据集来评估女性乳腺癌是否与慢性病毒性肝炎感染有关。
我们从索赔数据中确定了 1958 名在 2000-2008 年期间新诊断为乳腺癌的患者。选择了一个年龄匹配的、无癌症的 7832 名对照者随机队列进行比较。构建多变量逻辑回归模型，以计算在调整年龄、居住地区、职业、城市化和收入后，病毒性肝炎与乳腺癌相关的比值比。还评估了年龄特定（<50 岁和≥50 岁）的乳腺癌风险。
乳腺癌患者和对照组之间丙型肝炎病毒（HCV）感染、乙型肝炎病毒（HBV）或 HBV/HCV 合并感染的患病率没有显著差异（p=0.48）。然而，多变量逻辑回归分析显示，<50 岁的年龄与乳腺癌发病风险增加 2 倍相关（OR=2.03，95%CI=1.23-3.34）。
HCV 感染，而不是 HBV 感染，似乎与 HCV 和 HBV 流行地区的乳腺癌早发风险有关。这一发现需要在进一步的研究中得到复制。
