Su Fu-Hsiung, Bai Chyi-Huey, Le Thi Nga, Muo Chih-Hsin, Chang Shih-Ni, Te Arlene, Sung Fung-Chang, Yeh Chih-Ching
Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Front Oncol. 2021 Jan 8;10:561420. doi: 10.3389/fonc.2020.561420. eCollection 2020.
Studies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.
In this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases.
Results of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08-1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32-3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10-1.55, p = 0.03) in patients aged 50-59, and 1.10 (95% CI = 1.00-1.22, p = 0.061) in patients aged over 70.
Our findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients.
评估慢性丙型肝炎病毒（HCV）感染与结直肠癌（CRC）风险相关性的研究有限。
在这项病例对照研究中，我们识别出2005年至2011年新诊断的67670例CRC病例，并从同一数据库中随机选取67670名无HCV和CRC的对照，根据病例的年龄和性别进行频率匹配。
逻辑回归分析结果显示，慢性HCV感染相关的CRC调整优势比（aOR）为1.16（95%置信区间[CI]=1.08 - 1.24，p<0.001）。女性患CRC的风险略高于男性。风险随年龄降低，45岁以下患者的aOR从2.26（95%CI = 1.32 - 3.87，p = 0.003）降至50 - 59岁患者的1.31（95%CI = 1.10 - 1.55，p = 0.03），70岁以上患者的aOR为1.10（95%CI = 1.00 - 1.22，p = 0.061）。
我们的研究结果表明，慢性HCV感染患者患CRC的风险升高。我们的数据还表明，CRC预防项目需要针对年轻的HCV患者。
