Hussein Osama, El-Ghitany Engy Mohamed, Omran Mawadda, Matariek Ghadier, Elbadaly Esraa Ahmed, Hamdy Rana, Gamal Amira, Zayed Mai Mohamed, Nasr Ahmed, Hamdy Omar, Elbasiony Mohamed, Abdelwahab Khaled
Oncology Center and Department of Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Breast Cancer (Auckl). 2021 Mar 24;15:11782234211002499. doi: 10.1177/11782234211002499. eCollection 2021.
Hepatitis C virus (HCV) is a known risk factor for hepatocellular carcinoma. Several epidemiological studies have pointed out to an association of HCV infection with other extrahepatic malignancies. The role of chronic HCV in breast cancer causation is less clear. Egypt is an endemic area of HCV infection with resulting significant morbidity. The association between HCV status and breast cancer risk in Egyptian women is hitherto unknown.
A retrospective study was performed. The prevalence of anti-HCV seropositivity was estimated in a sample of women with a breast cancer diagnosis, retrieved from the hospital records, and was compared to the raw data of a population study in Egypt. Anti-HCV negative and positive patients were compared regarding the disease course and outcome.
Retrospective analysis revealed a markedly high prevalence of anti-HCV seropositivity in young breast cancer patients. In patients younger than 45 years, 13.4% were anti-HCV positive. Seropositivity was 6-fold higher in these patients than in adult females of the same age without cancer diagnosis ( = .003). The biological type, tumor size, nodal status, and disease-free survival were not affected by the patients' HCV status.
Young Egyptian breast cancer patients have a dramatically high prevalence of HCV seropositivity. Further population studies are strongly required to investigate the epidemiological association of these two significant health problems.
丙型肝炎病毒（HCV）是肝细胞癌已知的危险因素。多项流行病学研究指出HCV感染与其他肝外恶性肿瘤有关。慢性HCV在乳腺癌病因中的作用尚不清楚。埃及是HCV感染的流行地区，导致显著的发病率。埃及女性中HCV状态与乳腺癌风险之间的关联迄今未知。
进行了一项回顾性研究。从医院记录中检索出乳腺癌诊断女性样本，估计抗HCV血清阳性率，并与埃及一项人群研究的原始数据进行比较。比较抗HCV阴性和阳性患者的病程和结局。
回顾性分析显示年轻乳腺癌患者中抗HCV血清阳性率显著较高。在45岁以下的患者中，13.4%为抗HCV阳性。这些患者的血清阳性率比未患癌症诊断的同年龄成年女性高6倍（P = 0.003）。患者的HCV状态不影响生物学类型、肿瘤大小、淋巴结状态和无病生存期。
年轻埃及乳腺癌患者中HCV血清阳性率极高。强烈需要进一步的人群研究来调查这两个重大健康问题的流行病学关联。
