Chou Yi-Chun, Tsai Chi-Neu, Lee Yun-Shien, Pei Jen-Sheng
Department of Pediatrics, Taoyuan General Hospital, Taoyuan, Taiwan.
Pediatr Int. 2012 Feb;54(1):111-6. doi: 10.1111/j.1442-200X.2011.03516.x.
Polymorphisms of β2-adrenergic receptor (ADRB2) and β3-adrenergic receptor (ADRB3) have been reported to be associated with obesity in adults and adolescents, although study results have been controversial. The aim of the present study was to investigate the association of polymorphisms of ADRB2 (Arg16Gly, Gln27Glu) and ADRB3 (Trp64Arg) with adolescent obesity in Taiwan.
A total of 559 adolescent volunteers with equal numbers female and male were enrolled. Participants were divided into two groups: obese (body mass index [BMI]≥ 95th percentile) and normal weight (BMI 15th-85th percentile). Genomic DNA was extracted from buccal mucosa cells and genotyped in TaqMan assays. Genotype results and clinical subject characteristics were analyzed.
Among the three ADRB polymorphisms, only Arg16Gly polymorphism was found to be significantly correlated with adolescent obesity, especially in girls. Girls with genotype Gly/Gly had a lower probability of obesity than those with genotypes Arg/Gly or Arg/Arg (P= 0.006; Arg/Gly: odds ratio [OR], 2.57, 95% confidence interval [95%CI]: 1.22-5.41; Arg/Arg: OR, 3.03, 95%CI: 1.50-6.12). Girls with genotype Gly/Gly had lower BMI than those with genotype Arg/Arg (P= 0.049). Obese adolescents with genotype Gly/Gly had a lower probability of hypertension than those with genotype Arg/Gly or Arg/Arg (P= 0.005).
Arg16Gly polymorphism of ADRB2 was significantly associated with obesity in female adolescents, and those with the Gly/Gly genotype were associated with a lower possibility of obesity and lower BMI. This polymorphism was also associated with a lower probability of hypertension in obese adolescents. The other two polymorphisms of ADRB (Gln27Glu and Trp64Arg) were not associated with adolescent obesity in Taiwan.
β2-肾上腺素能受体（ADRB2）和β3-肾上腺素能受体（ADRB3）的多态性已被报道与成人及青少年肥胖相关，尽管研究结果存在争议。本研究旨在探讨ADRB2（Arg16Gly、Gln27Glu）和ADRB3（Trp64Arg）多态性与台湾青少年肥胖的关联。
共招募559名青少年志愿者，男女数量相等。参与者分为两组：肥胖组（体重指数[BMI]≥第95百分位数）和正常体重组（BMI第15 - 85百分位数）。从颊黏膜细胞中提取基因组DNA，并通过TaqMan分析进行基因分型。分析基因型结果和临床受试者特征。
在三种ADRB多态性中，仅发现Arg16Gly多态性与青少年肥胖显著相关，尤其是在女孩中。基因型为Gly/Gly的女孩肥胖概率低于基因型为Arg/Gly或Arg/Arg的女孩（P = 0.006；Arg/Gly：优势比[OR]，2.57，95%置信区间[95%CI]：1.22 - 5.41；Arg/Arg：OR，3.03，95%CI：1.50 - 6.12）。基因型为Gly/Gly的女孩BMI低于基因型为Arg/Arg的女孩（P = 0.049）。基因型为Gly/Gly的肥胖青少年患高血压的概率低于基因型为Arg/Gly或Arg/Arg的青少年（P = 0.005）。
ADRB2的Arg16Gly多态性与女性青少年肥胖显著相关，基因型为Gly/Gly的个体肥胖可能性较低且BMI较低。这种多态性还与肥胖青少年患高血压的概率较低有关。ADRB的其他两种多态性（Gln27Glu和Trp64Arg）与台湾青少年肥胖无关。
