Aksenov Vadim, Long Jiangang, Liu Jiankang, Szechtman Henry, Khanna Parul, Matravadia Sarthak, Rollo C David
Department of Biology, McMaster University, 1280 Main St W., Hamilton, ON, Canada.
Age (Dordr). 2013 Feb;35(1):23-33. doi: 10.1007/s11357-011-9325-2. Epub 2011 Nov 27.
We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.
我们研发了一种复合膳食补充剂，旨在抵消衰老的五个关键机制，并使用视觉线索莫里斯水迷宫试验测试其改善与年龄相关的认知衰退的有效性。所有年轻小鼠（<1岁）都能很好地学会这项任务。然而，未接受治疗的老年小鼠（>1岁）即使在5天后仍无法学会迷宫，这表明老年时认知能力严重衰退。相比之下，补充了该补充剂的老年小鼠即使在约2岁时也没有明显的认知衰退。补充了该补充剂的老年小鼠在定位平台方面比年龄匹配的对照组要好近50%。即使在年轻时，补充了该补充剂的小鼠的脑重量也显著大于对照组。补充剂使复合物III和IV的活性中的认知衰退逆转与认知改善显著相关，这意味着能量供应是一种可能的机制。这些结果证明了复合膳食补充剂可为认知功能和大脑衰老带来显著益处的原理。
