Southeast Veterinary Referral Center, Miami, FL 33143, USA. parmstrong@svrcfl orida.com
Med Mycol. 2012 Jul;50(5):509-12. doi: 10.3109/13693786.2011.633106. Epub 2011 Nov 28.
A bone marrow infection caused by Phialosimplex caninus was diagnosed in a seven-year-old female spayed Cocker Spaniel that was receiving prednisone for autoimmune hemolytic anemia. Histopathologic examination of a bone marrow core biopsy revealed clusters of oval to round yeast-like cells of varying shape and size and occasional irregular hyphae. Culture of a bone marrow aspirate sample yielded a mould initially suggestive of Paecilomyces inflatus or Sagenomella species but later determined to be P. caninus. The dog was treated with itraconazole and amphotericin B, and prednisone was continued at the lowest dose needed to control the hemolytic anemia. The patient died after 18 months of treatment. This is the first detailed clinical report of infection caused by P. caninus, a newly described fungus associated with disseminated disease in dogs.
一只七岁雌性已绝育可卡犬因自身免疫性溶血性贫血而接受泼尼松龙治疗，被诊断患有犬瓶霉引起的骨髓感染。骨髓芯活检的组织病理学检查显示，存在形状和大小不一的卵形到圆形酵母样细胞簇，偶尔还有不规则的菌丝。骨髓抽吸样本的培养最初显示出类似于膨孢拟青霉或 Sagenomella 属的霉菌，但后来确定为犬瓶霉。该犬接受了伊曲康唑和两性霉素 B 治疗，泼尼松龙继续以最低剂量使用以控制溶血性贫血。治疗 18 个月后，该犬死亡。这是首例有关犬瓶霉引起的感染的详细临床报告，犬瓶霉是一种新描述的真菌，与犬的播散性疾病有关。
