Bioengineering Program & Department of Industrial and Manufacturing Engineering, Wichita State University, 1845 Fairmount Street, Wichita, KS 67260, USA.
J Nanobiotechnology. 2011 Nov 28;9:55. doi: 10.1186/1477-3155-9-55.
Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.
可生物降解纳米颗粒 (NPs) 因其能够作为疫苗、基因、药物和其他生物分子在体内的靶向传递载体而受到越来越多的关注。它们提供了增强的生物相容性、更优的药物/疫苗包封以及方便的释放特性，可用于医学领域的多种药物、疫苗和生物分子的应用。在本文中，综述了可生物降解 NPs 的制备方法、影响最佳药物包封的各种因素、影响药物释放速率的因素、纳米颗粒的各种表面修饰以增强体内循环、分布和多模态功能以及特定应用，如肿瘤靶向、口服给药以及这些颗粒递送至中枢神经系统。
