The Department of Microbiology and Immunology, The University of Melbourne, Victoria, Australia.
J Leukoc Biol. 2012 Jul;92(1):97-106. doi: 10.1189/jlb.1011492. Epub 2011 Nov 28.
Airway MΦ and DCs are important components of innate host defense and can play a critical role in limiting the severity of influenza virus infection. Although it has been well established that cell-surface SA acts as a primary attachment receptor for IAV, the particular receptor(s) or coreceptor(s) that mediate IAV entry into any cell, including MΦ and DC, have not been clearly defined. Identifying which receptors are involved in attachment and entry of IAV into immune cells may have important implications in regard to understanding IAV tropism and pathogenesis. Recent evidence suggests that specialized receptors on MΦ and DCs, namely CLRs, can act as capture and/or entry receptors for many viral pathogens, including IAV. Herein, we review the early stages of infection of MΦ and DC by IAV. Specifically, we examine the potential role of CLRs expressed on MΦ and DC to act as attachment and/or entry receptors for IAV.
气道巨噬细胞和树突状细胞是先天宿主防御的重要组成部分，在限制流感病毒感染的严重程度方面可以发挥关键作用。尽管已经明确细胞表面唾液酸（SA）是甲型流感病毒（IAV）的主要附着受体，但介导 IAV 进入任何细胞（包括巨噬细胞和树突状细胞）的特定受体或辅助受体尚未明确界定。鉴定参与 IAV 附着和进入免疫细胞的受体对于理解 IAV 嗜性和发病机制可能具有重要意义。最近的证据表明，巨噬细胞和树突状细胞上的特异性受体，即 C 型凝集素受体（CLRs），可以作为许多病毒病原体（包括 IAV）的捕获和/或进入受体。在此，我们综述了 IAV 感染巨噬细胞和树突状细胞的早期阶段。具体而言，我们研究了巨噬细胞和树突状细胞上表达的 CLR 作为 IAV 的附着和/或进入受体的潜在作用。
