Federal State Budgetary Scientific Institution, Somov Research Institute of Epidemiology and Microbiology, Sel'skaya street, 1, Vladivostok 690087, Russia.
Far Eastern Federal University, School of Biomedicine, bldg. M25 FEFU Campus, Ajax Bay, Russky Isl., Vladivostok 690922, Russia.
Mar Drugs. 2019 Jun 22;17(6):373. doi: 10.3390/md17060373.
Seaweed metabolites (fucoidans, carrageenans, ulvans, lectins, and polyphenols) are biologically active compounds that target proteins or genes of the influenza virus and host components that are necessary for replication and reproduction of the virus.
This review gathers the information available in the literature regarding to the useful properties of seaweeds metabolites as potential agents for the prevention and therapy of influenza infection.
The sources of scientific literature were found in various electronic databases (i.e., PubMed, Web of Science, and ScienceDirect) and library search. The retrospective search depth is 25 years.
Influenza is a serious medical and social problem for humanity. Recently developed drugs are quite effective against currently circulating influenza virus strains, but their use can lead to the selection of resistant viral strains. In this regard, new therapeutic approaches and drugs with a broad spectrum of activity are needed. Metabolites of seaweeds fulfill these requirements. This review presents the results of in vitro and in vivo experimental and clinical studies about the effectiveness of these compounds in combating influenza infection and explains the necessity of their use as a potential basis for the creation of new drugs with a broad spectrum of activity.
海藻代谢物（褐藻糖胶、卡拉胶、岩藻聚糖、凝集素和多酚）是具有生物活性的化合物，可靶向流感病毒的蛋白质或基因以及宿主中对病毒复制和繁殖所必需的成分。
本综述汇集了文献中有关海藻代谢物作为预防和治疗流感感染的潜在药物的有用特性的信息。
科学文献的来源在各种电子数据库（即 PubMed、Web of Science 和 ScienceDirect）和图书馆检索中找到。回溯搜索深度为 25 年。
流感对人类来说是一个严重的医学和社会问题。最近开发的药物对目前流行的流感病毒株非常有效，但它们的使用可能导致抗病毒株的选择。在这方面，需要新的治疗方法和具有广谱活性的药物。海藻代谢物符合这些要求。本综述介绍了这些化合物在对抗流感感染方面的体外和体内实验以及临床研究的结果，并解释了将其用作广谱活性新药创制的潜在基础的必要性。
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