Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, PO Box 616, 6200 MD Maastricht, the Netherlands.
Diabetologia. 2012 May;55(5):1273-82. doi: 10.1007/s00125-011-2380-5. Epub 2011 Nov 29.
AIMS/HYPOTHESIS: The present study compares the impact of endurance- vs resistance-type exercise on subsequent 24 h blood glucose homeostasis in individuals with impaired glucose tolerance (IGT) and type 2 diabetes.
Fifteen individuals with IGT, 15 type 2 diabetic patients treated with exogenous insulin (INS), and 15 type 2 diabetic patients treated with oral glucose-lowering medication (OGLM) participated in a randomised crossover experiment. Participants were studied on three occasions for 3 days under strict dietary standardisation, but otherwise free-living conditions. Blood glucose homeostasis was assessed by ambulatory continuous glucose monitoring over the 24 h period following a 45 min session of resistance-type exercise (75% one repetition maximum), endurance-type exercise (50% maximum workload capacity) or no exercise at all.
Average 24 h blood glucose concentrations were reduced from 7.4 ± 0.2, 9.6 ± 0.5 and 9.2 ± 0.7 mmol/l during the control experiment to 6.9 ± 0.2, 8.6 ± 0.4 and 8.1 ± 0.5 mmol/l (resistance-type exercise) and 6.8 ± 0.2, 8.6 ± 0.5 and 8.5 ± 0.5 mmol/l (endurance-type exercise) over the 24 h period following a single bout of exercise in the IGT, OGLM and INS groups, respectively (p < 0.001 for both treatments). The prevalence of hyperglycaemia (blood glucose >10 mmol/l) was reduced by 35 ± 7 and 33 ± 11% over the 24 h period following a single session of resistance- and endurance-type exercise, respectively (p < 0.001 for both treatments).
CONCLUSIONS/INTERPRETATION: A single session of resistance- or endurance-type exercise substantially reduces the prevalence of hyperglycaemia during the subsequent 24 h period in individuals with IGT, and in insulin-treated and non-insulin-treated type 2 diabetic patients. Both resistance- and endurance-type exercise can be integrated in exercise intervention programmes designed to improve glycaemic control.
Clinicaltrials.gov NCT00945165.
The Netherlands Organization for Health Research and Development (ZonMw, the Netherlands).
目的/假设：本研究比较了耐力型和抗阻型运动对糖耐量受损（IGT）和 2 型糖尿病患者 24 小时血糖稳态的后续影响。
15 名 IGT 患者、15 名接受外源性胰岛素（INS）治疗的 2 型糖尿病患者和 15 名接受口服降糖药物（OGLM）治疗的 2 型糖尿病患者参加了一项随机交叉实验。在严格的饮食标准化条件下，参与者在 3 天内进行了 3 次研究，但在其他方面保持自由生活条件。通过在抗阻型运动（75%一次重复最大值）、耐力型运动（50%最大工作量）或不运动的情况下进行 45 分钟后，通过动态连续血糖监测评估 24 小时内的血糖稳态。
在 IGT、OGLM 和 INS 组中，与对照实验相比，平均 24 小时血糖浓度从 7.4±0.2、9.6±0.5 和 9.2±0.7mmol/l 分别降低至 6.9±0.2、8.6±0.4 和 8.1±0.5mmol/l（抗阻型运动）和 6.8±0.2、8.6±0.5 和 8.5±0.5mmol/l（耐力型运动）（两种治疗方法的 p 值均<0.001）。单次运动后 24 小时内，高血糖（血糖>10mmol/l）的发生率分别降低了 35±7%和 33±11%（两种治疗方法的 p 值均<0.001）。
结论/解释：单次抗阻或耐力型运动可显著降低 IGT 患者及接受胰岛素和非胰岛素治疗的 2 型糖尿病患者随后 24 小时内高血糖的发生率。抗阻型和耐力型运动均可纳入旨在改善血糖控制的运动干预计划。
Clinicaltrials.gov NCT00945165。
荷兰健康研究与发展组织（ZonMw，荷兰）。
