Department of Human Physiology and Sports Medicine, Vrije Universiteit Brussel, Brussels, Belgium.
Diabetologia. 2009 Sep;52(9):1789-97. doi: 10.1007/s00125-009-1354-3. Epub 2009 Apr 16.
AIMS/HYPOTHESIS: Exercise represents an effective interventional strategy to improve glycaemic control in type 2 diabetes patients. However, the impact of exercise intensity on the benefits of exercise training remains to be established. In the present study, we compared the clinical benefits of 6 months of continuous low- to moderate-intensity exercise training with those of continuous moderate- to high-intensity exercise training, matched for energy expenditure, in obese type 2 diabetes patients.
Fifty male obese type 2 diabetes patients (age 59 +/- 8 years, BMI 32 +/- 4 kg/m(2)) participated in a 6 month continuous endurance-type exercise training programme. All participants performed three supervised exercise sessions per week, either 55 min at 50% of whole body peak oxygen uptake (VO(2)peak (low to moderate intensity) or 40 min at 75% of VO(2)peak (moderate to high intensity). Oral glucose tolerance, blood glycated haemoglobin, lipid profile, body composition, maximal workload capacity, whole body and skeletal muscle oxidative capacity and skeletal muscle fibre type composition were assessed before and after 2 and 6 months of intervention.
The entire 6 month intervention programme was completed by 37 participants. Continuous endurance-type exercise training reduced blood glycated haemoglobin levels, LDL-cholesterol concentrations, body weight and leg fat mass, and increased VO(2)peak, lean muscle mass and skeletal muscle cytochrome c oxidase and citrate synthase activity (p < 0.05). No differences were observed between the groups training at low to moderate or moderate to high intensity.
CONCLUSIONS/INTERPRETATION: When matched for energy cost, prolonged continuous low- to moderate-intensity endurance-type exercise training is equally effective as continuous moderate- to high-intensity training in lowering blood glycated haemoglobin and increasing whole body and skeletal muscle oxidative capacity in obese type 2 diabetes patients.
ISRCTN32206301
None.
目的/假设：运动是改善 2 型糖尿病患者血糖控制的有效干预策略。然而，运动强度对运动训练益处的影响尚待确定。本研究比较了 6 个月持续低-中强度运动训练与持续中-高强度运动训练对肥胖 2 型糖尿病患者的临床益处，两种运动训练的能量消耗相当。
50 名男性肥胖 2 型糖尿病患者（年龄 59 ± 8 岁，BMI 32 ± 4 kg/m²）参加了 6 个月的持续耐力型运动训练计划。所有参与者每周进行 3 次监督下的运动，运动强度分别为全身峰值摄氧量（VO2peak）的 50%（低-中强度）持续 55 分钟或 75%（中-高强度）持续 40 分钟。在干预前、2 个月和 6 个月后评估口服葡萄糖耐量、糖化血红蛋白、血脂谱、身体成分、最大工作能力、全身和骨骼肌氧化能力以及骨骼肌纤维类型组成。
37 名参与者完成了整个 6 个月的干预计划。持续耐力型运动训练降低了糖化血红蛋白水平、LDL 胆固醇浓度、体重和腿部脂肪量，增加了 VO2peak、瘦肌肉量以及骨骼肌细胞色素 c 氧化酶和柠檬酸合酶活性（p<0.05）。低-中强度和中-高强度运动组之间未观察到差异。
结论/解释：当能量消耗相匹配时，持续低-中强度耐力型运动训练与持续中-高强度训练一样有效，可以降低肥胖 2 型糖尿病患者的糖化血红蛋白水平，并增加全身和骨骼肌的氧化能力。
ISRCTN32206301
无。
