Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Diabetes Care. 2012 Jan;35(1):175-7. doi: 10.2337/dc11-1775. Epub 2011 Nov 28.
The purpose of this study was to determine whether age influences the association between obesity and hyperglycemia.
The subjects were 57,576 Japanese male and female workers aged 35-70 years. The associations of adiposity indices, including BMI, waist circumference, and waist-to-height ratio, with risk for hyperglycemia were compared among different age groups (35-39, 40-49, 50-59, and 60-70 years) using odds ratios (ORs).
There were significant trends for the crude ORs of obese subjects versus nonobese subjects for hyperglycemia to be lower as age increased in men and women. Multivariate logistic regression analysis showed these trends of age-dependent decreases in ORs for hyperglycemia were not altered by adjustment for confounders such as smoking, alcohol drinking, and habitual exercise.
The results suggest that the association between obesity and hyperglycemia declines with age in men and women.
本研究旨在确定年龄是否会影响肥胖与高血糖之间的关联。
本研究对象为 57576 名年龄在 35-70 岁的日本男性和女性工人。采用比值比（OR）比较不同年龄组（35-39 岁、40-49 岁、50-59 岁和 60-70 岁）中肥胖指数（BMI、腰围和腰高比）与高血糖风险之间的关联。
在男性和女性中，与非肥胖者相比，肥胖者发生高血糖的粗 OR 随着年龄的增长而降低，且呈明显趋势。多变量 logistic 回归分析显示，这些年龄相关的高血糖 OR 降低趋势在调整了吸烟、饮酒和习惯性运动等混杂因素后并未改变。
这些结果表明，在男性和女性中，肥胖与高血糖之间的关联随着年龄的增长而降低。
