Economidou Sophia N, Pissinato Pere Cristiane P, Okereke Michael, Douroumis Dennis
Medway School of Pharmacy, University of Kent, Medway Campus, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK.
Department of Engineering Science, University of Greenwich, Kent ME4 4TB, UK.
Micromachines (Basel). 2021 Jan 22;12(2):117. doi: 10.3390/mi12020117.
3D printing has emerged as a powerful manufacturing technology and has attracted significant attention for the fabrication of microneedle (MN)-mediated transdermal systems. In this work, we describe an optimisation strategy for 3D-printed MNs, ranging from the design to the drug delivery stage. The key relationships between design and manufacturing parameters and quality and performance are systematically explored. The printing and post-printing set parameters were found to influence quality and material mechanical properties, respectively. It was demonstrated that the MN geometry affected piercing behaviour, fracture, and coating morphology. The delivery of insulin in porcine skin by inkjet-coated MNs was shown to be influenced by MN design.
3D打印已成为一种强大的制造技术，并在微针介导的透皮系统制造方面引起了广泛关注。在这项工作中，我们描述了一种3D打印微针的优化策略，涵盖从设计到药物递送阶段。系统地探索了设计与制造参数以及质量与性能之间的关键关系。发现打印参数和打印后设置的参数分别影响质量和材料机械性能。结果表明，微针的几何形状会影响穿刺行为、断裂情况和涂层形态。喷墨涂层微针在猪皮中递送胰岛素的情况显示受微针设计的影响。
