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3D打印微针：革新透皮给药系统。

3D printed microneedles: revamping transdermal drug delivery systems.

作者信息

Prabhu Ashlesh, Baliga Vishal, Shenoy Raghavendra, Dessai Akanksha D, Nayak Usha Y

机构信息

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

出版信息

Drug Deliv Transl Res. 2025 Feb;15(2):436-454. doi: 10.1007/s13346-024-01679-7. Epub 2024 Aug 5.

DOI:10.1007/s13346-024-01679-7
PMID:39103595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11683023/
Abstract

One of the advancements of the transdermal drug delivery system (TDDS) is the development of microneedles (MNs). These micron-sized needles are used for delivering various types of drugs to address the disadvantage of other transdermal techniques as well as oral drug delivery systems. MNs have high patient acceptance due to self-administration with minimally invasive and pain compared to the parenteral drug delivery. Over the years, various methods have been adopted to evolve the MNs and make them more cost-effective, accurate, and suitable for multiple applications. One such method is the 3D printing of MNs. The development of MN platforms using 3D printing has been made possible by improved features like precision, printing resolution, and the feasibility of using low-cost raw materials. In this review, we have tried to explain various types of MNs, fabrication methods, materials used in the formulation of MNs, and the recent applications that utilize 3D-printed MNs.

摘要

透皮给药系统（TDDS）的进展之一是微针（MNs）的开发。这些微米级的针用于递送各种类型的药物，以解决其他透皮技术以及口服给药系统的缺点。与肠胃外给药相比，微针具有微创和疼痛小的特点，患者接受度高。多年来，人们采用了各种方法来改进微针，使其更具成本效益、更精确且适用于多种应用。3D打印微针就是这样一种方法。利用3D打印开发MN平台，得益于诸如精度、打印分辨率以及使用低成本原材料的可行性等改进特性而成为可能。在这篇综述中，我们试图解释各种类型的微针、制造方法、微针制剂中使用的材料，以及利用3D打印微针的最新应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/ca3df3a070d0/13346_2024_1679_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/a62647da5889/13346_2024_1679_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/09ee23de3908/13346_2024_1679_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/f7e649b41a15/13346_2024_1679_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/11f5f577e299/13346_2024_1679_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/010c03816070/13346_2024_1679_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/235c649bb330/13346_2024_1679_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/ca3df3a070d0/13346_2024_1679_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/a62647da5889/13346_2024_1679_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/09ee23de3908/13346_2024_1679_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/f7e649b41a15/13346_2024_1679_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/11f5f577e299/13346_2024_1679_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/010c03816070/13346_2024_1679_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/235c649bb330/13346_2024_1679_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ed/11683023/ca3df3a070d0/13346_2024_1679_Fig7_HTML.jpg

相似文献

[1]
3D printed microneedles: revamping transdermal drug delivery systems.

Drug Deliv Transl Res. 2025-2

[2]
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[4]
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[5]
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[6]
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Biosensors (Basel). 2022-7-6

[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Polymeric 3D-Printed Microneedle Arrays for Non-Transdermal Drug Delivery and Diagnostics.

Polymers (Basel). 2025-7-18

[2]
Unique advantages and applications of polysaccharide microneedles as drug delivery materials and in treatment of skin diseases.

Nanoscale Adv. 2025-4-12

[3]
Angiostatin: a promising therapeutic target for atopic dermatitis.

Arch Dermatol Res. 2025-3-22

[4]
Etodolac utility in osteoarthritis: drug delivery challenges, topical nanotherapeutic strategies and potential synergies.

Ther Deliv. 2024

本文引用的文献

[1]
3D printing of polypropylene reinforced with hemp fibers: Mechanical, water absorption and morphological properties.

Heliyon. 2024-2-17

[2]
3D printing of polylactic acid: recent advances and opportunities.

Int J Adv Manuf Technol. 2023

[3]
Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review.

Int J Pharm X. 2023-1-3

[4]
3D-Printed Integrated Ultrasonic Microneedle Array for Rapid Transdermal Drug Delivery.

Mol Pharm. 2022-9-5

[5]
3D-Printed Polypyrrole Microneedle Arrays for Electronically Controlled Transdural Drug Release.

ACS Biomater Sci Eng. 2022-4-11

[6]
3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients.

Nat Commun. 2021-10-29

[7]
Advances in microneedle-based transdermal delivery for drugs and peptides.

Drug Deliv Transl Res. 2022-7

[8]
An overview on the advantages and limitations of 3D printing of microneedles.

Pharm Dev Technol. 2021-11

[9]
Recent advances in transdermal drug delivery systems: a review.

Biomater Res. 2021-7-28

[10]
Development and preclinical evaluation of microneedle-assisted resveratrol loaded nanostructured lipid carriers for localized delivery to breast cancer therapy.

Int J Pharm. 2021-9-5

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