Zimmerling Amanda, Chen Xiongbiao
Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Bioprinting. 2020 Dec;20:e00104. doi: 10.1016/j.bprint.2020.e00104. Epub 2020 Sep 28.
Infectious diseases have the ability to impact health on a global scale, as is being demonstrated by the current coronavirus disease 2019 (COVID-19) pandemic. The strenuous circumstances related to this global health crisis have been highlighting the challenges faced by the biomedical field in combating infectious diseases. Notably, printing technologies have advanced rapidly over the last decades, allowing for the incorporation of living cells in the printing process (or bioprinting) to create constructs that are able to serve as tissue or virus-disease models in combating infectious diseases. This paper describes applications of bioprinting in addressing the challenges faced in combating infectious diseases, with a specific focus on modelling and on development of therapeutic agents and vaccines. Integration of these technologies may allow for a more efficient and effective response to current and future pandemics.
传染病有能力在全球范围内影响健康,当前的2019冠状病毒病(COVID-19)大流行就证明了这一点。与这场全球健康危机相关的严峻形势一直在凸显生物医学领域在抗击传染病方面所面临的挑战。值得注意的是,在过去几十年里打印技术发展迅速,使得在打印过程中能够纳入活细胞(即生物打印),从而创建出可作为抗击传染病的组织或病毒-疾病模型的构建体。本文描述了生物打印在应对抗击传染病所面临挑战方面的应用,特别关注模型构建以及治疗剂和疫苗的研发。整合这些技术可能会使我们对当前和未来的大流行做出更高效、更有效的应对。