Martin P
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Science. 1997 Apr 4;276(5309):75-81. doi: 10.1126/science.276.5309.75.
The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
成人皮肤伤口的愈合是一个复杂的过程，需要许多不同组织和细胞谱系的协同努力。目前，人们大致了解了每种参与细胞类型在增殖、迁移、基质合成和收缩阶段的行为，以及伤口部位存在的生长因子和基质信号。这些信号如何控制伤口细胞活动的细节正开始显现，对胚胎愈合的研究已开始表明正常的成人修复过程如何可能被重新调整，使其更少像修补而更像再生。
