Institute of Animal Nutrition, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinä rplatz 1,Vienna, Austria.
J Anim Physiol Anim Nutr (Berl). 2013 Feb;97(1):155-61. doi: 10.1111/j.1439-0396.2011.01253.x. Epub 2011 Nov 30.
Concentration profile of zearalenone (ZON) and its metabolites in plasma, urine and faeces samples of horses fed with Fusarium toxin-contaminated oats is described. In plasma, β-zearalenol (β-ZOL) was detected at high levels on day 10 of the study (3.21-6.24 μg/l). β-Zearalenol and α-zearalenol were the major metabolites in urine. Zearalenone, α-ZOL and β-ZOL were predominantly found in faeces. Zearalanone could also be detected in urine (1.34-5.79 μg/l) and faeces (1 μg/kg). The degree of glucuronidation was established in all sample types, approximately 100% in urine and plasma. Low per cent of glucuronidation (4-15%) was found in faeces samples. The results indicate the main conversion of ZON into β-ZOL in horse. This finding could explain why horse is not susceptible to ZON in comparison with swine which produce α-ZOL as a predominant metabolite.
本文描述了在喂食被镰刀菌毒素污染的燕麦的马的血浆、尿液和粪便样本中，玉米赤霉烯酮（ZON）及其代谢物的浓度分布。在研究的第 10 天，β-玉米赤霉醇（β-ZOL）在血浆中被检测到高浓度（3.21-6.24μg/l）。β-ZOL 和 α-ZOL 是尿液中的主要代谢物。ZON、α-ZOL 和 β-ZOL 主要存在于粪便中。玉米赤烯酮也可以在尿液（1.34-5.79μg/l）和粪便（1μg/kg）中检测到。在所有样本类型中都确定了葡萄糖醛酸化的程度，尿液和血浆中约为 100%。粪便样本中的葡萄糖醛酸化程度较低（4-15%）。研究结果表明，马体内 ZON 主要转化为β-ZOL。这一发现可以解释为什么与产生主要代谢物α-ZOL 的猪相比，马不易受到 ZON 的影响。
