mTOR 信号通路
mTOR Signaling.
机构信息
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Université Laval, Québec, Canada.
出版信息
Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2):a011593. doi: 10.1101/cshperspect.a011593.
Abstract
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates environmental cues (e.g., growth factors and energy status) to control cell growth and proliferation.
摘要
哺乳动物雷帕霉素靶蛋白（mTOR）是一种丝氨酸/苏氨酸激酶，可整合环境信号（例如生长因子和能量状态）来控制细胞生长和增殖。
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本文引用的文献
1
mTOR: from growth signal integration to cancer, diabetes and ageing.mTOR：从生长信号整合到癌症、糖尿病和衰老。
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15.
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An emerging role of mTOR in lipid biosynthesis.mTOR 在脂质生物合成中的新作用。
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mTOR signaling at a glance.mTOR信号通路概述。
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Molecular mechanisms of mTOR-mediated translational control.mTOR介导的翻译控制的分子机制。
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5
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.酵母中的雷帕霉素靶蛋白TOR2是G1期进程所必需的一种重要磷脂酰肌醇激酶同源物。
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A mammalian protein targeted by G1-arresting rapamycin-receptor complex.一种受G1期阻滞雷帕霉素受体复合物作用的哺乳动物蛋白。
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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.在哺乳动物细胞中分离FKBP12-雷帕霉素复合物的蛋白质靶点。
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8
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.RAFT1：一种以雷帕霉素依赖方式与FKBP12结合且与酵母TORs同源的哺乳动物蛋白。
Cell. 1994 Jul 15;78(1):35-43. doi: 10.1016/0092-8674(94)90570-3.
9
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.免疫抑制剂雷帕霉素在酵母中引起细胞周期停滞的靶点。
Science. 1991 Aug 23;253(5022):905-9. doi: 10.1126/science.1715094.
10
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.雷帕霉素（AY - 22,989），一种新型抗真菌抗生素。I. 产生该抗生素的链霉菌的分类及活性成分的分离
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