神经生物学中的光学标记分子。
Optical highlighter molecules in neurobiology.
机构信息
Department of Neurobiology, Harvard Medical School, Room 336 Warren Alpert Bldg., 220 Longwood Avenue, Boston, MA 02115, United States.
出版信息
Curr Opin Neurobiol. 2012 Feb;22(1):111-20. doi: 10.1016/j.conb.2011.11.007. Epub 2011 Nov 28.
Abstract
The development of advanced optical methods has played a key role in propelling progress in neurobiology. Genetically-encoded fluorescent molecules found in nature have enabled labeling of individual neurons to study their physiology and anatomy. Here we discuss the recent use of both native and synthetic optical highlighter proteins to address key problems in neurobiology, including questions relevant to synaptic function, neuroanatomy, and the organization of neural circuits.
摘要
先进的光学方法的发展在推动神经生物学的进步方面发挥了关键作用。在自然界中发现的遗传编码荧光分子使我们能够对单个神经元进行标记，以研究它们的生理学和解剖学。在这里，我们讨论了天然和合成光学标记蛋白的最新应用，以解决神经生物学中的关键问题，包括与突触功能、神经解剖学和神经网络组织相关的问题。
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