Yamauchi T, Funakoshi A, Wakasugi H, Hayakawa A, Ibayashi H
Gastroenterol Jpn. 1979;14(2):122-8. doi: 10.1007/BF02773583.
We studied serum carcinoembryonic antigen (CEA) levels in 82 patients. Thirty-four of these had benign diseases while 48 had malignant diseases. Highest incidence and levels of CEA occurred in the sera of patients with pancreatic cancer and stomach cancer. In this paper we focused our particular attention on the serum CEA of 25 pancreatic cancer patients, and examined differences in serum CEA levels in relation to histologic differentiation and sites of pancreatric cancer. No statistical difference in serum CEA level was found among various histologic types and sites of the pancreatic cancer. Clinical courses of two patients with pancreatic cancer were also studied. Serial determinations of CEA levels are most useful in assessing the effect of operation or chemotherapies and are a useful indicator for differentiating pancreatic cancer from chronic pancreatitis but cannot be a conclusive factor for the diagnosis. Finally, we correlated serum CEA levels with those of RNase and confirmed a positive correlation.
我们研究了82例患者的血清癌胚抗原（CEA）水平。其中34例患有良性疾病，48例患有恶性疾病。CEA的最高发病率和水平出现在胰腺癌和胃癌患者的血清中。在本文中，我们特别关注了25例胰腺癌患者的血清CEA，并研究了血清CEA水平与胰腺癌组织学分化和部位的差异。在胰腺癌的各种组织学类型和部位之间，血清CEA水平未发现统计学差异。还研究了两名胰腺癌患者的临床病程。连续测定CEA水平在评估手术或化疗效果方面最有用，是区分胰腺癌与慢性胰腺炎的有用指标，但不能作为诊断的决定性因素。最后，我们将血清CEA水平与核糖核酸酶水平进行了关联，证实了两者呈正相关。
