组织多肽抗原在诊断胰腺癌方面比血清癌胚抗原更准确吗？
Is tissue polypeptide antigen more accurate than serum CEA for diagnosing pancreatic cancer?
作者信息
Panucci A, Fabris C, Del Favero G, Basso D, Di Mario F, Marchioro L, Piccoli A, Lise M, Burlina A, Naccarato R
出版信息
J Clin Pathol. 1986 Jan;39(1):75-7. doi: 10.1136/jcp.39.1.75.
Tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) were determined in the sera of 36 control subjects, 30 patients with pancreatic cancer, 35 with chronic pancreatitis and 25 with non-pancreatic digestive disease to evaluate their role in detecting pancreatic malignancy. Abnormal values of TPA and CEA were found in 28 and 19 of 30 patients with pancreatic cancer, and in four and seven of 35 patients with chronic pancreatitis, respectively. Raised titres of TPA were observed more often than equivalent serum CEA in simulated pancreatic diseases. The receiver-operating (ROC) characteristic curves showed that TPA was more discriminating than CEA in detecting pancreatic cancer. Specificity was enhanced when both titres were abnormally high and sensitivity when one titre was raised, but the diagnostic accuracy of TPA alone has not improved, which satisfactorily discriminates pancreatic cancer from chronic pancreatitis.
检测36名对照者、30例胰腺癌患者、35例慢性胰腺炎患者及25例非胰腺消化系统疾病患者血清中的组织多肽抗原（TPA）和癌胚抗原（CEA），以评估它们在检测胰腺恶性肿瘤中的作用。30例胰腺癌患者中，TPA和CEA异常值分别见于28例和19例；35例慢性胰腺炎患者中，分别见于4例和7例。在模拟胰腺疾病中，TPA升高的发生率高于同等血清CEA。受试者工作特征（ROC）曲线显示，在检测胰腺癌方面，TPA比CEA更具鉴别力。当两种指标均异常升高时特异性增强，当一种指标升高时敏感性增强，但单独TPA的诊断准确性并未提高，其能令人满意地将胰腺癌与慢性胰腺炎区分开来。
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