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通过免疫组织化学法检测癌胚抗原（CEA）在正常、慢性炎症及恶性胰腺组织中的表达。

Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.

作者信息

Allum W H, Stokes H J, Macdonald F, Fielding J W

出版信息

J Clin Pathol. 1986 Jun;39(6):610-4. doi: 10.1136/jcp.39.6.610.

DOI:10.1136/jcp.39.6.610
PMID:3522636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC499967/
Abstract

The expression of carcinoembryonic antigen (CEA) was evaluated by immunoperoxidase staining with two anti-CEA monoclonal antibodies in normal, chronically inflamed, and malignant pancreatic tissue. Positive staining was not observed in normal specimens. In pancreatic cancer the expression of CEA was related to the degree of differentiation of the tumour. Positive staining was also observed in chronic pancreatitis.

摘要

采用两种抗癌胚抗原（CEA）单克隆抗体，通过免疫过氧化物酶染色法对正常胰腺组织、慢性炎症胰腺组织及胰腺恶性肿瘤组织中CEA的表达情况进行了评估。正常标本中未观察到阳性染色。在胰腺癌中，CEA的表达与肿瘤的分化程度相关。在慢性胰腺炎中也观察到了阳性染色。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/898a/499967/17313a0f6068/jclinpath00201-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/898a/499967/17313a0f6068/jclinpath00201-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/898a/499967/17313a0f6068/jclinpath00201-0029-a.jpg

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1
Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue by immunohistochemistry.通过免疫组织化学法检测癌胚抗原（CEA）在正常、慢性炎症及恶性胰腺组织中的表达。
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本文引用的文献

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Cancer Res. 1980 Aug;40(8 Pt 2):2984-92.
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Factors controlling the circulating CEA levels in pancreatic cancer: some clinical correlations.胰腺癌中控制循环癌胚抗原水平的因素：一些临床相关性
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Tumor localization of radio-labeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.
转移性胰腺癌的治疗进展：聚焦于靶向治疗
Ther Adv Med Oncol. 2022 Sep 6;14:17588359221118019. doi: 10.1177/17588359221118019. eCollection 2022.
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Overview and Future Perspectives on Tumor-Targeted Positron Emission Tomography and Fluorescence Imaging of Pancreatic Cancer in the Era of Neoadjuvant Therapy.新辅助治疗时代胰腺癌的肿瘤靶向正电子发射断层扫描和荧光成像概述及未来展望
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Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors.人类类器官与原发性胰腺腺癌肿瘤在结构和遗传特征上具有相似性。
Mol Cancer Res. 2019 Jan;17(1):70-83. doi: 10.1158/1541-7786.MCR-18-0531. Epub 2018 Aug 31.
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Combination Immunotherapy Approaches for Pancreatic Cancer Treatment.联合免疫治疗方法治疗胰腺癌。
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