Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea.
Vet J. 2012 Jul;193(1):222-7. doi: 10.1016/j.tvjl.2011.10.022. Epub 2011 Nov 29.
Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n=37). Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.
调节性 T 细胞（Treg）通过抑制抗肿瘤免疫在肿瘤进展中发挥关键作用，但在兽医肿瘤学中尚未得到充分记录。为了确定肿瘤微环境中 Treg 细胞的特征，分析了 Treg 细胞的数量，并将其与犬乳腺肿瘤（MC）组织中的组织学预后因素和分子生物标志物进行了比较（n=37）。大量的 Treg 细胞与高组织学分级和淋巴浸润有关。在具有不良预后因素（如高组织学分级、淋巴浸润和坏死）的肿瘤中，浸润肿瘤内区域的 Treg 细胞数量明显增加。这些发现表明 Treg 细胞在犬 MC 进展中发挥作用。此外，肿瘤内区 Treg 细胞的数量在评估犬 MC 时可能提供一个潜在的预后因素，这可能反过来导致新的免疫治疗方法的发展。
