NRPSsp：非核糖体肽合成酶底物预测器。
NRPSsp: non-ribosomal peptide synthase substrate predictor.
机构信息
Institute of Biotechnology of Leon, INBIOTEC, Parque Científico de León, 24006 León, Spain.
出版信息
Bioinformatics. 2012 Feb 1;28(3):426-7. doi: 10.1093/bioinformatics/btr659. Epub 2011 Nov 29.
SUMMARY
Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity. The discovery and characterization of non-ribosomal peptides are of great interest for the biotechnological industries. We have applied computational mining methods in order to build a database of NRPSs modules that bind to specific substrates. We have used this database to build a hidden Markov model predictor of substrates that bind to a given NRPS.
AVAILABILITY
The database and the predictor are freely available on an easy-to-use website at www.nrpssp.com.
CONTACT
SUPPLEMENTARY INFORMATION
Supplementary data is available at Bioinformatics online.
摘要
非核糖体肽合成酶（NRPSs）是多模块酶，可生物合成细菌和真菌产生的许多重要肽类化合物。一些研究表明，NRPSs 中的单个结构域表现出显著的底物选择性。非核糖体肽的发现和特性对于生物技术产业具有重要意义。我们应用了计算挖掘方法来构建与特定底物结合的 NRPS 模块数据库。我们使用该数据库构建了一个针对给定 NRPS 结合底物的隐马尔可夫模型预测器。
可用性
数据库和预测器可在易于使用的网站 www.nrpssp.com 上免费获取。
联系方式
补充信息
补充数据可在“Bioinformatics”在线获取。
Zotero 插件