Prasad D S, Kabir Zubair, Dash A K, Das B C
Consultant Cardiologist, Sudhir Heart Centre Main Road, Dharmanagar, Berhampur, India.
J Cardiovasc Dis Res. 2011 Oct;2(4):199-205. doi: 10.4103/0975-3583.89803.
Evidence is emerging that obesity-associated cardiovascular disorders (CVD) show variations across regions and ethnicities. However, it is unclear if there are distinctive patterns of abdominal obesity contributing to an increased CVD risk in South Asians. Also, potential underlying mechanistic pathways of such unique patterns are not comprehensively reported in South Asians. This review sets out to examine both. A comprehensive database search strategy was undertaken, namely, PubMed, Embase and Cochrane Library, applying specific search terms for potentially relevant published literature in English language. Grey literature, including scientific meeting abstracts, expert consultations, text books and government/non-government publications were also retrieved. South Asians have 3-5% higher body fat than whites, at any given body mass index. Additional distinctive features, such as South Asian phenotype, low adipokine production, lower lean body mass, ethno-specific socio-cultural and economic factors, were considered as potential contributors to an early age-onset of obesity-linked CVD risk in South Asians. Proven cost-effective anti-obesity strategies, including the development of ethno-specific clinical risk assessment tools, should be adopted early in the life-course to prevent premature CVD deaths and morbidity in South Asians.
越来越多的证据表明，与肥胖相关的心血管疾病（CVD）在不同地区和种族中存在差异。然而，目前尚不清楚南亚人群中是否存在导致心血管疾病风险增加的独特腹部肥胖模式。此外，南亚人群中这种独特模式的潜在机制途径尚未得到全面报道。本综述旨在对这两方面进行研究。我们采用了全面的数据库检索策略，即在PubMed、Embase和Cochrane图书馆中，使用特定的检索词搜索潜在相关的英文已发表文献。还检索了灰色文献，包括科学会议摘要、专家咨询、教科书以及政府/非政府出版物。在任何给定的体重指数下，南亚人的体脂比白人高3%-5%。其他独特特征，如南亚人的体型、低脂肪因子产生、较低的瘦体重、特定种族的社会文化和经济因素，被认为是南亚人肥胖相关心血管疾病风险早发的潜在因素。应在生命早期采用经证实具有成本效益的抗肥胖策略，包括开发特定种族的临床风险评估工具，以预防南亚人心血管疾病过早死亡和发病。
