Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
J Clin Anesth. 2011 Dec;23(8):636-42. doi: 10.1016/j.jclinane.2011.04.008.
To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability.
Single-center, prospective, randomized clinical trial.
Academic outpatient clinic.
40 ASA physical status 1 and 2 patients with intellectual disability.
Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol.
The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded.
BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening.
Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
研究在智力残疾的牙科患者中使用基于双频谱指数（BIS）的靶控输注（TCI）进行异丙酚镇静的效果。
单中心、前瞻性、随机临床试验。
学术门诊。
40 名 ASA 身体状况 1 级和 2 级的智力残疾患者。
患者随机分为两组。手动控制（MC）组（n = 20）通过手动控制异丙酚输注进行镇静，不使用 BIS 指数监测仪。BIS-TCI 组（n = 20）通过 BIS 指导的异丙酚 TCI 进行镇静。
记录所需的异丙酚剂量、睫毛反射恢复时间和自主睁眼时间。
BIS-TCI 显著降低了异丙酚的剂量，并缩短了睫毛反射和自主睁眼的恢复时间。
BIS 指导的 TCI 异丙酚镇静是智力残疾患者管理的一种有效且安全的方法。
