Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Psychiatr Res. 2012 Mar;46(3):389-93. doi: 10.1016/j.jpsychires.2011.11.010. Epub 2011 Dec 3.
Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-α and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-α and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-α, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD.
双相情感障碍（BD）与更高的慢性合并症、超重和肥胖有关。脂联素是脂肪细胞衍生的分泌因子，具有免疫反应功能，似乎与 BD 和超重都有关。本研究的目的是评估超重的双相情感障碍患者与超重对照组相比，脂联素、抵抗素和瘦素以及 TNF-α及其受体（sTNFR1 和 sTNFR2）的血浆水平。通过 Mini-International Neuropsychiatric Interview、Young Mania 和 Hamilton Depression 评分量表（分别为 YMRS 和 HDRS）评估了 30 名病情稳定的 BD 型 I 患者和 30 名年龄、性别和体重指数（BMI）匹配的对照组。通过 ELISA 测量了脂联素、抵抗素、瘦素、TNF-α及其可溶性受体的血浆水平。BD 患者的脂联素（p < 0.001）、瘦素（p < 0.001）和 sTNFR1（p = 0.01）的血浆水平升高。脂联素的血浆水平与临床参数以及 TNF-α、sTNFR1 和 sTNFR2 的血浆水平均无相关性。本研究为 BD 中免疫/炎症失衡的假说提供了进一步的支持。
