Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing.
Chin J Integr Med. 2011 Dec;17(12):903-7. doi: 10.1007/s11655-011-0933-6. Epub 2011 Dec 3.
To explore the effectiveness related indicators which might help identify the indications of Tongxinluo Capsule () and Kangxin Capsule () targeting on qi deficiency and blood stasis pattern in Chinese medicine (CM) in the treatment of angina pectoris.
The data from a multicenter, randomized and double-blinded study conducted at 5 centers in China were obtained for the analysis. A total of 239 patients with angina pectoris and CM syndrome of qi deficiency and blood stasis were randomly assigned in a 1:1 ratio to Tongxinluo Capsule group (119 cases) and Kangxin Capsule group (120 cases). Angina effectiveness and electrocardiogram (ECG) improvement were selected as the therapeutic outcomes.
After a 4-week treatment, the effective rates of Tongxinluo Capsule and Kangxin Capsule were 43.70% and 25.00%, respectively (P <0.05). Serum low-density lipoprotein (LDL) level was found to influence the effectiveness of Tongxinluo Capsule which had higher effective rate in the patients with lower level of LDL. Heart rate was found to influence the effectiveness in the patients treated with Kangxin Capsule which had higher effective rate in the patients with heart rate [Symbol: see text]80 beats/min.
LDL level and heart rate were the indicators which help indentify the indications of Tongxinluo Capsule and Kangxin Capsule, respectively, in the treatment of angina pectoris with CM syndrome of qi deficiency and blood stasis.
探讨有助于识别通心络胶囊（）和康欣胶囊（）针对中医（CM）气阴两虚证治疗心绞痛适应证的有效性相关指标。
对中国 5 家中心进行的多中心、随机、双盲研究的数据进行了分析。共 239 例心绞痛伴 CM 气阴两虚证患者按 1:1 比例随机分为通心络胶囊组（119 例）和康欣胶囊组（120 例）。选择心绞痛疗效和心电图（ECG）改善作为治疗结局。
治疗 4 周后，通心络胶囊和康欣胶囊的有效率分别为 43.70%和 25.00%（P <0.05）。血清低密度脂蛋白（LDL）水平影响通心络胶囊的疗效，LDL 水平较低的患者有效率更高。心率影响康欣胶囊的疗效，心率 [Symbol: see text]80 次/分钟的患者有效率更高。
LDL 水平和心率分别是识别通心络胶囊和康欣胶囊治疗 CM 气阴两虚证心绞痛适应证的指标。
