诺托酰胺E：在杂色曲霉NRRL 35600培养物中生物合成掺入诺托酰胺C和D。
Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600.
作者信息
Finefield Jennifer M, Greshock Thomas J, Sherman David H, Tsukamoto Sachiko, Williams Robert M
机构信息
Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, Colorado 80523, U.S.A.
出版信息
Tetrahedron Lett. 2011 Apr 20;52(16):1987-1989. doi: 10.1016/j.tetlet.2011.02.078.
Abstract
Notoamide E, a short-lived secondary metabolite, has been proposed as a biosynthetic intermediate to several advanced metabolites isolated from Aspergillus versicolor. In order to verify the role of this indole alkaloid along the biosynthetic pathway, synthetic doubly (13)C-labeled notoamide E was fed to Aspergillus versicolor. Analysis of the metabolites showed significant incorporation of notoamide E into the natural products notoamides C and D.
摘要
诺托酰胺E是一种寿命短暂的次生代谢产物，已被认为是从杂色曲霉中分离出的几种高级代谢产物的生物合成中间体。为了验证这种吲哚生物碱在生物合成途径中的作用，将合成的双（13）C标记的诺托酰胺E喂给杂色曲霉。对代谢产物的分析表明，诺托酰胺E大量掺入天然产物诺托酰胺C和D中。
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