Sugimoto Kayo, Sadahiro Yusaku, Kagiyama Ippei, Kato Hikaru, Sherman David H, Williams Robert M, Tsukamoto Sachiko
Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.
Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.
Tetrahedron Lett. 2017 Jul 19;58(29):2797-2800. doi: 10.1016/j.tetlet.2017.05.057. Epub 2017 May 18.
A new prenylated alkaloid, Amoenamide A (), was isolated from the fungus NRRL 35600. Previously, was postulated to be a precursor of Notoamide E4 () converted from Notoamide E (), which was a key precursor of the prenylated indole alkaloids in the fungi of the genus . We previously succeeded in the isolation of two pairs of antipodes, Stephacidin A () and Notoamide B (), from and MF297-2 and expected the presence of other antipodes in the culture of . We here report five new antipodes () along with a new metabolite (), which was isolated as a natural compound for the first time, from .
从真菌NRRL 35600中分离出一种新的异戊烯基化生物碱，即Amoenamide A（）。此前，曾推测（）是由Notoamide E（）转化而来的Notoamide E4（）的前体，而Notoamide E是该属真菌中异戊烯基化吲哚生物碱的关键前体。我们之前成功地从和MF297-2中分离出两对对映体，即Stephacidin A（）和Notoamide B（），并预计在的培养物中存在其他对映体。在此，我们报道了从分离出的五个新对映体（）以及一种新的代谢产物（），该代谢产物首次作为天然化合物被分离出来。
