从NRRL 35600中分离出阿莫酰胺A和五种对映异戊烯基化生物碱。
Isolation of amoenamide A and five antipodal prenylated alkaloids from NRRL 35600.
作者信息
Sugimoto Kayo, Sadahiro Yusaku, Kagiyama Ippei, Kato Hikaru, Sherman David H, Williams Robert M, Tsukamoto Sachiko
机构信息
Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.
Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.
出版信息
Tetrahedron Lett. 2017 Jul 19;58(29):2797-2800. doi: 10.1016/j.tetlet.2017.05.057. Epub 2017 May 18.
Abstract
A new prenylated alkaloid, Amoenamide A (), was isolated from the fungus NRRL 35600. Previously, was postulated to be a precursor of Notoamide E4 () converted from Notoamide E (), which was a key precursor of the prenylated indole alkaloids in the fungi of the genus . We previously succeeded in the isolation of two pairs of antipodes, Stephacidin A () and Notoamide B (), from and MF297-2 and expected the presence of other antipodes in the culture of . We here report five new antipodes () along with a new metabolite (), which was isolated as a natural compound for the first time, from .
摘要
从真菌NRRL 35600中分离出一种新的异戊烯基化生物碱，即Amoenamide A（）。此前，曾推测（）是由Notoamide E（）转化而来的Notoamide E4（）的前体，而Notoamide E是该属真菌中异戊烯基化吲哚生物碱的关键前体。我们之前成功地从和MF297-2中分离出两对对映体，即Stephacidin A（）和Notoamide B（），并预计在的培养物中存在其他对映体。在此，我们报道了从分离出的五个新对映体（）以及一种新的代谢产物（），该代谢产物首次作为天然化合物被分离出来。
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