菲滇啶 A 和 B 的结构和细胞毒性：海洋天然产物中首次发现 1,2,4-噁二唑系统。
Structure and cytotoxicity of phidianidines A and B: first finding of 1,2,4-oxadiazole system in a marine natural product.
机构信息
Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Pozzuoli (Na), Italy.
出版信息
Org Lett. 2011 May 20;13(10):2516-9. doi: 10.1021/ol200234r. Epub 2011 Apr 20.
PMID:21506595
Abstract
Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.
摘要
两种吲哚生物碱，phidianidines A（1）和 B（2），具有不常见的 1,2,4-噁二唑环连接到吲哚系统，已从海洋腹足纲软体动物 Phidiana militaris 中分离出来。两种代谢产物的结构通过光谱技术阐明。在体外试验中，phidianidines 对肿瘤和非肿瘤哺乳动物细胞系表现出高细胞毒性。
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