Gordeets A V, Iurusova E N, Smagina A N, Piskunova S L
Antibiot Khimioter. 2011;56(5-6):49-53.
Characteristics of the clinical process and immunological profile in children with yersiniosis as a monoinfection or in association with acute intenstinal infections and virus hepatitis A are presented. The efficacy of the immunotropic therapy with cycloferon, an interferon inductor, and recombinant interferon in the patients with the viral and bacterial association of the disease (yersiniosis + hepatitis A) and initial disbalance of the serum cytokines was estimated. Dependence of the interferon clinicolaboratory efficacy on the initial levels of serum y-interferon, IL2 and IIA, promoting shorter terms of hyperthermia, diarrhea syndrome and cytolysis syndrome was shown. It allowed to optimize the scheme of the pathogenetic therapy of Yersinia mixed infection.
本文介绍了耶尔森菌病作为单一感染或与急性肠道感染及甲型病毒性肝炎合并感染时儿童的临床过程特征和免疫谱。评估了在疾病病毒与细菌合并感染（耶尔森菌病+甲型肝炎）且血清细胞因子初始失衡的患者中，使用干扰素诱导剂环磷酰胺和重组干扰素进行免疫调节治疗的疗效。结果显示，干扰素的临床实验室疗效取决于血清γ干扰素、白细胞介素2和白细胞介素1A的初始水平，这些指标可促进缩短发热、腹泻综合征和细胞溶解综合征的持续时间。这有助于优化耶尔森菌混合感染的发病机制治疗方案。
