Crit Care. 2011;15(6):1016. doi: 10.1186/cc10531. Epub 2011 Dec 5.
Lactic acid was first discovered in human blood in 1843. Since then it has been used as a prognosticator of outcome in critical illness. Regardless of its etiology, lactate's presence and trend over time have been shown to be independently associated with mortality. Two dynamic lactate measures, the time-weighted average lactate and the absolute change in lactate over the first 24 hours in the ICU, were recently shown to be better than static lactate measurements in predicting hospital and ICU deaths.
乳酸于 1843 年首次在人血中被发现。从那时起，它就被用作危重病患者预后的预测指标。无论其病因如何，乳酸的存在及其随时间的变化趋势都与死亡率独立相关。最近的研究表明，两种动态乳酸指标，即 ICU 内 24 小时内的时间加权平均乳酸和第一个 24 小时内的乳酸绝对变化，在预测医院和 ICU 死亡方面优于静态乳酸测量。
