[中国西南地区丙型肝炎病毒6a亚型的传播速度]
[The velocity of HCV subtype 6a transmission in southwest China].
作者信息
Hong Guo-hu, Tan Zhao-xia, Guo Yan, Mao Qing
机构信息
PLA Institute of Infectious Diseases, the Third Military Medical University, Chongqing, China.
出版信息
Zhonghua Gan Zang Bing Za Zhi. 2011 Jul;19(7):502-5. doi: 10.3760/cma.j.issn.1007-3418.2011.07.009.
OBJECTIVE
To estimate the velocity of HCV subtype 6a transmission in Southwest China.
METHODS
The HCV CE1 region from 61 patients infected with HCV genotype 6 were amplificated by RT-PCR and sequenced. The subtypes were identified, and the period of HCV 6a strains originated in southwest china was estimated by using molecular clock phylogenetic analysis. The velocity of HCV subtype 6a transmission in southwest China was estimated by BEAST v1.6.1 and Tracer v1.5 software theoretically.
RESULTS
Most of HCV 6a strains distributed in Southwest China origine around the year 1968 and at last 4 epidemic strains existed. The earlier origine strains could be isolated both in intravenous drug users (IDU) and non-IDU patients. After 1997, the HCV 6a strains transmission in southwest China accelerated and the trend intensified in 2007.
CONCLUSION
HCV 6a strains spread fastly both in IDU and non-IDU patients, which might be the main HCV subtype distributed in Southwest China in the future.
目的
评估中国西南地区丙型肝炎病毒6a亚型的传播速度。
方法
采用逆转录聚合酶链反应（RT-PCR）扩增61例丙型肝炎病毒基因型6感染者的HCV CE1区并测序。鉴定亚型，运用分子钟系统发育分析估计起源于中国西南地区的HCV 6a毒株的出现时间。理论上通过BEAST v1.6.1和Tracer v1.5软件评估中国西南地区HCV 6a亚型的传播速度。
结果
中国西南地区的大多数HCV 6a毒株起源于1968年左右，且至少存在4个流行毒株。较早起源的毒株在静脉吸毒者（IDU）和非IDU患者中均可分离到。1997年后，中国西南地区HCV 6a毒株的传播加速，并于2007年趋势增强。
结论
HCV 6a毒株在IDU和非IDU患者中均传播迅速，可能是未来中国西南地区主要的HCV亚型。
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