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来自五脉绿绒蒿的前所未有的糠醛-2-甲酰基 C-糖苷和酚性二糖苷。

Unprecedented furan-2-carbonyl C-glycosides and phenolic diglycosides from Scleropyrum pentandrum.

机构信息

Chulabhorn Research Institute and Chulabhorn Graduate Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand.

出版信息

Phytochemistry. 2012 Feb;74:115-22. doi: 10.1016/j.phytochem.2011.11.001. Epub 2011 Dec 5.

Abstract

Five unprecedented furan-2-carbonyl C-glycosides, scleropentasides A-E, and two phenolic diglycosides, 4-hydroxy-3-methoxybenzyl 4-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside and 2,6-dimethoxy-p-hydroquinone 1-O-β-D-xylopyranosyl-(1→6)-β-d-glucopyranoside, were isolated from leaves and twigs of Scleropyrum pentandrum together with potalioside B, luteolin 6-C-β-D-glucopyranoside (isoorientin), apigenin 8-C-β-D-glucopyranoside (vitexin), apigenin 6,8-di-C-β-D-glucopyranoside (vicenin-2), apigenin 6-C-α-L-arabinopyranosyl-8-C-β-D-glucopyranoside (isoschaftoside), apigenin 6-C-β-D-glucopyranosyl-8-C-β-D-xylopyranoside, adenosine and l-tryptophan. Structure elucidations of these compounds were based on analyses of chemical and spectroscopic data, including 1D and 2D NMR. In addition, the isolated compounds were evaluated for their radical scavenging activities using both DPPH and ORAC assays.

摘要

从五脉黑三棱的叶和小枝中分离得到了五个前所未有的呋喃-2-甲酰基 C-糖苷,即 scleropentaside A-E,以及两个酚性二糖苷,4-羟基-3-甲氧基苄基 4-O-β-D-吡喃木糖基-(1→6)-β-D-吡喃葡萄糖苷和 2,6-二甲氧基对苯二酚 1-O-β-D-吡喃木糖基-(1→6)-β-D-吡喃葡萄糖苷,此外还有 potalioside B、木犀草素 6-C-β-D-吡喃葡萄糖苷(异荭草苷)、芹菜素 8-C-β-D-吡喃葡萄糖苷(牡荆素)、芹菜素 6,8-二-C-β-D-吡喃葡萄糖苷(vicenin-2)、芹菜素 6-C-α-L-阿拉伯吡喃糖苷-8-C-β-D-吡喃葡萄糖苷(异荭草苷)、芹菜素 6-C-β-D-吡喃葡萄糖苷-8-C-β-D-木糖苷、腺苷和 l-色氨酸。这些化合物的结构解析是基于化学和光谱数据分析,包括 1D 和 2D NMR。此外,还通过 DPPH 和 ORAC 测定法评估了分离得到的化合物的自由基清除活性。

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