University of Groningen, Department of Oral Health Care and Clinical Epidemiology, Centre for Dentistry and Oral Hygiene University Medical Centre Groningen, Groningen, The Netherlands.
J Dent Res. 2012 Feb;91(2):173-8. doi: 10.1177/0022034511431260. Epub 2011 Dec 8.
The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocentesis procedure was carried out. In one group, the procedure was followed by the administration of a single-dose intra-articular dexamethasone. In the other group, saline was administered as a control. Follow-up visits were scheduled after 1, 3, and 24 weeks. During each visit, TMJ pain (on a 100-mm VAS) and jaw stiffness (mouth opening in mm) were scored. In the statistical analysis, generalized estimating equation (GEE) models showed no differences between the two study groups, although pain and jaw stiffness were both reduced over 24 weeks. In conclusion, intra-articular dexamethasone following arthrocentesis did not improve the procedure's effect in patients presenting with TMJ arthralgia (ClinicalTrials.gov number CT01275014).
本研究旨在比较关节内注射地塞米松与安慰剂（生理盐水）在颞下颌关节（TMJ）关节穿刺后的疗效。28 名 TMJ 关节痛患者被随机分为平行双盲 RCT 的两组。两组均行关节穿刺术。一组在关节内注射单剂量地塞米松，另一组给予生理盐水作为对照。在第 1、3 和 24 周进行随访。每次就诊时，均对 TMJ 疼痛（100mm VAS）和下颌僵硬（张口毫米数）进行评分。在统计分析中，广义估计方程（GEE）模型显示两组间无差异，尽管疼痛和下颌僵硬在 24 周内均减轻。总之，关节内注射地塞米松并未改善 TMJ 关节痛患者关节穿刺术的效果（ClinicalTrials.gov 编号 CT01275014）。
