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本文引用的文献

1
Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here.自闭症谱系障碍的神经影像学研究述评:我们已经学到了什么,以及未来的方向。
Mol Autism. 2011 Apr 18;2(1):4. doi: 10.1186/2040-2392-2-4.
2
Paternal age and psychiatric disorders: findings from a Dutch population registry.父亲年龄与精神障碍:来自荷兰人口登记处的研究结果。
Schizophr Res. 2011 Jul;129(2-3):128-32. doi: 10.1016/j.schres.2011.03.021. Epub 2011 Apr 12.
3
Parental ages and levels of DNA methylation in the newborn are correlated.父母年龄与新生儿的 DNA 甲基化水平相关。
BMC Med Genet. 2011 Mar 31;12:47. doi: 10.1186/1471-2350-12-47.
4
Autism and increased paternal age related changes in global levels of gene expression regulation.自闭症与父代年龄增加相关的基因表达调控的全球水平变化。
PLoS One. 2011 Feb 17;6(2):e16715. doi: 10.1371/journal.pone.0016715.
5
Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.父龄相关精神分裂症(PARS):通过 K 均值聚类分析检测到的潜在亚组。
Schizophr Res. 2011 May;128(1-3):143-9. doi: 10.1016/j.schres.2011.02.006. Epub 2011 Feb 26.
6
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.端粒酶和端粒结合蛋白的端粒和端粒外作用。
Nat Rev Cancer. 2011 Mar;11(3):161-76. doi: 10.1038/nrc3025.
7
An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects.人类端粒生物学的进化研究综述:节俭端粒假说及潜在适应性父系效应的注释。
Am J Hum Biol. 2011 Mar-Apr;23(2):149-67. doi: 10.1002/ajhb.21127. Epub 2010 Dec 17.
8
Meiotic recombination errors, the origin of sperm aneuploidy and clinical recommendations.减数分裂重组错误、精子非整倍体的起源和临床建议。
Syst Biol Reprod Med. 2011 Feb;57(1-2):93-101. doi: 10.3109/19396368.2010.504879. Epub 2011 Jan 4.
9
The effect of paternal age on assisted reproduction outcome.父亲年龄对辅助生殖结局的影响。
Fertil Steril. 2011 Jan;95(1):1-8. doi: 10.1016/j.fertnstert.2010.08.029. Epub 2010 Oct 8.
10
Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.关键期与疾病的发育起源:精神分裂症的表观遗传学观点。
Ann N Y Acad Sci. 2010 Sep;1204 Suppl(0):E8-13. doi: 10.1111/j.1749-6632.2010.05644.x.

高龄父亲与生殖结局。

Advanced paternal age and reproductive outcome.

机构信息

Fertility and IVF Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

出版信息

Asian J Androl. 2012 Jan;14(1):69-76. doi: 10.1038/aja.2011.69. Epub 2011 Dec 12.

DOI:10.1038/aja.2011.69
PMID:22157982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3735149/
Abstract

Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

摘要

近年来,女性越来越晚地开始生育。这种趋势同样也出现在男性身上。母亲年龄对生育能力、染色体异常、妊娠并发症以及后代围产期和产后结局的影响已经得到了深入研究,这些方面在生育和孕前咨询中得到了临床应用。男性衰老和生殖结局相对较少受到关注。本文旨在评估关于父亲年龄对生殖结局影响的最新相关文献。