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肾乳头状甲状腺癌样肿瘤:一例报告

Papillary thyroid carcinoma-like tumor of the kidney: a case report.

作者信息

Khoja Hatim A, Almutawa Abdulmonem, Binmahfooz Ali, Aslam Muhammad, Ghazi Abdullah A, Almaiman Sara

机构信息

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

出版信息

Int J Surg Pathol. 2012 Aug;20(4):411-5. doi: 10.1177/1066896911429942. Epub 2011 Dec 7.

Abstract

Thyroid carcinoma-like tumor of the kidney is an extremely rare variant of renal cell carcinoma. Most previously reported cases were incidental finding; and none of them showed papillary thyroid carcinoma (PTC) nuclear features. This study reports the first case of PTC (follicular variant)-like tumor of the kidney in which a female patient presented with hematuria, weight loss, and flank pain. Imaging studies revealed a left renal mass with enlarged hilar lymph nodes. Histologically, the renal tumor had a striking resemblance to follicular variant of PTC. However, no radiological abnormalities were found in the thyroid, mediastinum, or pelvis. Tumor cells were negative for thyroid markers (thyroglobulin and TTF1). According to the authors, this is the first case of PTC (follicular variant)-like tumor of the kidney.

摘要

肾甲状腺癌样肿瘤是肾细胞癌一种极其罕见的变异类型。既往报道的大多数病例均为偶然发现,且均未表现出乳头状甲状腺癌(PTC)的核特征。本研究报告了首例肾PTC(滤泡状变异型)样肿瘤,该女性患者表现为血尿、体重减轻和胁腹疼痛。影像学检查显示左肾肿块伴肾门淋巴结肿大。组织学上,肾肿瘤与PTC滤泡状变异型极为相似。然而,甲状腺、纵隔或盆腔未发现放射学异常。肿瘤细胞甲状腺标志物(甲状腺球蛋白和TTF1)呈阴性。据作者称,这是首例肾PTC(滤泡状变异型)样肿瘤。

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