Department of Chemistry G. Ciamician, University of Bologna, Via Selmi 2, 40126, Bologna, Italy.
Nanoscale. 2012 Feb 7;4(3):824-30. doi: 10.1039/c1nr11401h. Epub 2011 Dec 12.
Biocompatible highly bright silica nanoparticles were designed, prepared and tested in small living organisms for both in vivo and ex vivo imaging. The results that we report here demonstrate that they are suitable for optical imaging applications as a possible alternative to commercially available fluorescent materials including quantum dots. Moreover, the tunability of their photophysical properties, which was enhanced by the use of different dyes as doping agents, constitutes a very important added value in the field of medical diagnostics.
我们设计、制备并在小型活体生物中测试了生物相容性的高亮硅纳米颗粒，用于体内和离体成像。我们在这里报告的结果表明，它们适用于光学成像应用，可作为包括量子点在内的商业荧光材料的一种替代材料。此外，通过使用不同染料作为掺杂剂来增强其光物理性质的可调谐性，在医学诊断领域具有非常重要的附加价值。
