Department of Anaesthetics, Royal Infirmary, Edinburgh.
J Psychopharmacol. 1988 Jan;2(1):19-25. doi: 10.1177/026988118800200104.
In two randomized double-blind crossover studies, 8 and 10 healthy volunteers took either 200 mg caffeine or placebo. Objective and subjective measures of caffeine effects were carried out over the following 1-3.5 h. Auditory vigilance, a test lasting 1 h, showed significantly better performance on caffeine than on placebo. In the second study, this effect was only apparent in the second half of the test. Of the shorter objective tests used, only finger tapping showed a significant effect of caffeine, the rate of tapping over 1 min being increased. The subjective assessments showed increased interest and alertness in the caffeine session. Reliable detection of the effects of mild stimulant drugs using objective measures may require the use of tests of long duration.
在两项随机、双盲交叉研究中，8 名和 10 名健康志愿者分别服用 200 毫克咖啡因或安慰剂。在接下来的 1-3.5 小时内，对咖啡因的客观和主观影响进行了测量。持续 1 小时的听觉警戒测试显示，咖啡因组的表现明显优于安慰剂组。在第二项研究中，这种效果仅在测试的后半段才明显。在所使用的较短的客观测试中，只有手指轻敲显示出咖啡因的显著效果，即 1 分钟内的轻敲次数增加。主观评估显示，咖啡因组的兴趣和警觉性有所提高。使用客观措施可靠地检测轻度兴奋剂的效果可能需要使用长时间的测试。
