Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto 860-8556, Japan.
Jpn J Radiol. 2012 Jan;30(1):25-33. doi: 10.1007/s11604-011-0003-1. Epub 2011 Dec 14.
To investigate the chronological relationship between scan delay and liver enhancement for the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI and evaluate the effects of liver function on liver enhancement.
Hepatobiliary-phase images were retrospectively evaluated in 125 patients with chronic liver disease. Hepatobiliary phase images were obtained at 5, 10, 15, and 20 min after injection. We calculated relative liver enhancement (RLE) at t min after injection by dividing the signal intensity (SI) of the liver at t min by precontrast SI. We compared RLE values at 5, 10, 15, and 20 min and evaluated the detectability of focal hepatic lesions. We analyzed the effect of liver function on RLE with the generalized linear model.
There was not significant difference in RLE and lesion detectability at 15 and 20 min. RLE in the Child-Pugh C group was significantly lower than in the Child-Pugh A and B groups. The serum albumin level and prothrombin time were significantly correlated with the liver enhancement.
A delay time of 15 min for the hepatobiliary phase was thought to be adequate in patients with mild liver dysfunction. The serum albumin level and prothrombin time would be predictive of liver enhancement in the hepatobiliary phase.
研究钆塞酸二钠增强 MRI 肝胆期扫描延迟时间与肝脏强化之间的时间关系，并评估肝功能对肝脏强化的影响。
回顾性分析 125 例慢性肝病患者的肝胆期图像。肝胆期图像在注射后 5、10、15 和 20 min 获得。通过将 t min 时肝脏的信号强度（SI）除以预对比 SI，计算 t min 时的相对肝脏强化（RLE）。比较了 5、10、15 和 20 min 的 RLE 值，并评估了局灶性肝病变的检出率。用广义线性模型分析肝功能对 RLE 的影响。
15 min 和 20 min 时 RLE 和病变检出率无显著差异。Child-Pugh C 组的 RLE 明显低于 Child-Pugh A 和 B 组。血清白蛋白水平和凝血酶原时间与肝脏强化显著相关。
对于肝功能轻度异常的患者，肝胆期的延迟时间 15 min 可能是足够的。血清白蛋白水平和凝血酶原时间可预测肝胆期的肝脏强化。
