Sepah Yasir J, Hatef Elham, Colantuoni Elizabeth, Wang Jianmin, Shulman Mathew, Adhi Fatima Idrees, Akhtar Abeer, Ibrahim Mohamed, Khwaja Afsheen, Channa Roomasa, Sophie Raafay, Bittencourt Millena, Heo Jangwon, Do Diana V, Nguyen Quan Dong
Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Ophthalmic Inflamm Infect. 2012 Jun;2(2):65-73. doi: 10.1007/s12348-011-0052-8. Epub 2011 Dec 14.
This study aims to investigate the relationship between macular sensitivity and thickness in eyes with uveitic macular edema (UME).
This study is a prospective observational case series.
The setting for this study was clinical practice. The study included 59 (28 with UME, 31 without UME) eyes of 26 patients with uveitis and 19 eyes of 10 normal subjects. The procedure followed was fundus-related perimetry and retinal thickness map with an automated fundus perimetry/tomography system. Main outcome measures included quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and thickness.
Fixation stability revealed that 56 eyes (93.44%) had stable fixation (>75% within the central 2° of point of fixation); three eyes (6.56%) were relatively unstable (<75% of fixation points located within 2°, >75% located within 4°); and no eye had unstable fixation (<75% of fixation points located within 4°). Evaluation of fixation location revealed that 45 eyes (76.27%) had central fixation location (>50% of fixation point within 0.5 mm of foveal center); seven eyes (11.86%) had peri-central fixation location (25% << 50% within 0.5 mm); and seven eyes (11.86%) had eccentric (<25% of fixation point within 0.5 mm) fixation location. We measured macular sensitivity and corresponding thickness in 1,708 loci of 61 study eyes. Macular sensitivity increased by 0.02 dB (95% confidence interval, 0.00, 0.06) per 1 μm increase in the thickness for the thickness values ≤280 μm. Macular sensitivity decreased by 0.04 dB (95% CI, -0.08, -0.01) per 1 μm increase in the thickness for the thickness values >280 μm.
Perimetry quantification of macular sensitivity and retinal thickness, in association with other factors, may offer novel information regarding the impact of UME on retinal function.
本研究旨在探讨葡萄膜炎性黄斑水肿（UME）患者黄斑敏感度与厚度之间的关系。
本研究为前瞻性观察性病例系列研究。
本研究的背景为临床实践。研究纳入了26例葡萄膜炎患者的59只眼（28只患有UME，31只未患UME）以及10名正常受试者的19只眼。所采用的检查方法为使用自动眼底视野计/断层扫描系统进行与眼底相关的视野检查和视网膜厚度测量。主要观察指标包括黄斑敏感度的量化、注视模式以及黄斑敏感度与厚度之间的关系。
注视稳定性显示，56只眼（93.44%）具有稳定的注视（注视点中心2°范围内>75%）；3只眼（6.56%）相对不稳定（2°范围内注视点<75%，4°范围内>75%）；没有眼的注视不稳定（4°范围内注视点<75%）。注视位置评估显示，45只眼（76.27%）具有中心注视位置（注视点在黄斑中心0.5毫米范围内>50%）；7只眼（11.86%）具有中心周围注视位置（0.5毫米范围内25%＜注视点＜50%）；7只眼（11.86%）具有偏心注视位置（0.5毫米范围内注视点<25%）。我们在61只研究眼中的1708个位点测量了黄斑敏感度和相应厚度。对于厚度值≤280μm的情况，厚度每增加1μm，黄斑敏感度增加0.02dB（95%置信区间，0.00，0.06）。对于厚度值>280μm的情况，厚度每增加1μm，黄斑敏感度降低0.04dB（95%CI，-0.08，-0.01）。
黄斑敏感度和视网膜厚度的视野定量测量，结合其他因素，可能提供有关UME对视网膜功能影响的新信息。
