Humanitas Clinical and Research Center-IRCCS, Via Manzoni 56, 20089 Rozzano (MI), Italy.
Int J Mol Sci. 2021 Jan 27;22(3):1224. doi: 10.3390/ijms22031224.
Nowadays, it is well accepted that inflammation is a critical player in cancer, being, in most cases, the main character of the process. Different types of tumor arise from sites of infection or chronic inflammation. This non-resolving inflammation is responsible for tumor development at different levels: it promotes tumor initiation, as well as tumor progression, stimulating both tumor growth and metastasis. Environmental factors, lifestyle and infections are the three main triggers of chronic immune activation that promote or increase the risk of many different cancers. In this review, we focus our attention on tumor onset; in particular, we summarize the knowledge about the cause and the mechanisms behind the inflammation-driven cancer development.
如今，人们普遍认为炎症是癌症的关键因素，在大多数情况下，它是这一过程的主要角色。不同类型的肿瘤起源于感染或慢性炎症部位。这种未解决的炎症负责在不同层面促进肿瘤的发展：它促进肿瘤的发生，以及肿瘤的进展，刺激肿瘤的生长和转移。环境因素、生活方式和感染是慢性免疫激活的三个主要触发因素，促进或增加了许多不同癌症的风险。在这篇综述中，我们将注意力集中在肿瘤的发生上；特别是，我们总结了关于炎症驱动的癌症发展的原因和机制的知识。
