Institute for Public Health Genetics, University of Washington, Seattle, WA 98195, USA.
Sci Transl Med. 2011 Dec 14;3(113):113cm34. doi: 10.1126/scitranslmed.3002788.
The scientific and public health benefits of mandatory data-sharing mechanisms must be actively demonstrated. To this end, we manually reviewed 2724 data access requests approved between June 2007 and August 2010 through the U.S. National Center for Biotechnology Information database of genotypes and phenotypes (dbGaP). Our analysis demonstrates that dbGaP enables a wide range of secondary research by investigators from academic, governmental, and nonprofit and for-profit institutions in the United States and abroad. However, limitations in public reporting preclude the tracing of outcomes from secondary research to longer-term translational benefit.
必须积极证明强制性数据共享机制在科学和公共卫生方面的益处。为此,我们通过美国国家生物技术信息中心的基因型和表型数据库(dbGaP)手动审查了 2007 年 6 月至 2010 年 8 月期间批准的 2724 项数据访问请求。我们的分析表明,dbGaP 使来自美国和国外的学术、政府、非营利和营利机构的研究人员能够进行广泛的二次研究。然而,公共报告的局限性使得无法将二次研究的结果追溯到更长期的转化效益。