National Guard Health Affairs & King Abdullah International Medical Research Center, Research Genetic Laboratory, Riyadh, Saudi Arabia.
Virol J. 2011 Dec 18;8:548. doi: 10.1186/1743-422X-8-548.
The aim of this study is to assess the epidemiology along with the molecular structure of rotavirus causing pediatric diarrhea among Saudi patients. However, in this report we sited the epidemiological reflect coming from our project.
One thousand and seven diarrheal stool samples had been collected between Jan 1st, 2008 and OCT 31st, 2010 from hospitalized patients below the age of 5 year. Samples were then examined using Enzyme-linked immunosorbent assay (ELISA). Demographic data were collected including age, sex, date of admission and discharge. Finally, the chi-squire test, α level of significance was used to test the variables in the data.
Of these 1007 stool samples, rotavirus was detected in 65.5% (660/1007 samples). We observed that children who are 1 year of age or less had more infection with rotavirus 81% (534/660) than those who is over 1 year of age (19%,126/660) (P = 0.000). Infections occur throughout the year with no clear significant seasonal peaks. The difference between males (57.5%, 380/660) and females (42.4%, 280/660) in terms of rotavirus positivity is statistically significant.
The high rate of positivity, are at variance with previously published reports of rotavirus infection in Saudi Arabia since 2005 which reported a major decrease year by year in the incidence of rotavirus over; 2005, 2006 and 2008 with percentage of; 25%, 10%, 6% respectively explained by improvements in public health introduced in recent years. Our increasing rate result (65.5%) may suggest emerging of unusual serotypes, not been represent to our country earlier.
本研究旨在评估沙特儿童腹泻轮状病毒的流行病学及分子结构。然而，在本报告中，我们引用了我们项目的流行病学反映。
2008 年 1 月 1 日至 2010 年 10 月 31 日期间，我们从 5 岁以下住院患者中收集了 1007 份腹泻粪便样本。然后使用酶联免疫吸附试验（ELISA）进行检查。收集了人口统计学数据，包括年龄、性别、入院和出院日期。最后，使用卡方检验，α 显著性水平检验数据中的变量。
在这 1007 份粪便样本中，65.5%（660/1007 份）检测到轮状病毒。我们观察到 1 岁或以下的儿童感染轮状病毒的比例为 81%（534/660），高于 1 岁以上的儿童（19%，126/660）（P=0.000）。感染全年发生，无明显季节性高峰。男性（57.5%，380/660）和女性（42.4%，280/660）在轮状病毒阳性方面的差异具有统计学意义。
高阳性率与沙特阿拉伯自 2005 年以来发表的轮状病毒感染报告不一致，2005 年、2006 年和 2008 年轮状病毒发病率逐年显著下降，分别为 25%、10%和 6%，这可以解释为近年来公共卫生的改善。我们不断增加的发生率（65.5%）可能表明出现了我国以前没有出现过的不寻常血清型。
