Nuffield Department of Obstetrics and Gynaecology, and Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.
Am J Obstet Gynecol. 2012 Feb;206(2):119-23. doi: 10.1016/j.ajog.2011.10.866. Epub 2011 Oct 25.
Preterm birth is a syndrome with many causes and phenotypes. We propose a classification that is based on clinical phenotypes that are defined by ≥ 1 characteristics of the mother, the fetus, the placenta, the signs of parturition, and the pathway to delivery. Risk factors and mode of delivery are not included. There are 5 components in a preterm birth phenotype: (1) maternal conditions that are present before presentation for delivery, (2) fetal conditions that are present before presentation for delivery, (3) placental pathologic conditions, (4) signs of the initiation of parturition, and (5) the pathway to delivery. This system does not force any preterm birth into a predefined phenotype and allows all relevant conditions to become part of the phenotype. Needed data can be collected from the medical records to classify every preterm birth. The classification system will improve understanding of the cause and improve surveillance across populations.
早产是一种病因和表型多样的综合征。我们提出了一种分类方法，该方法基于临床表型，这些表型由母亲、胎儿、胎盘、分娩迹象和分娩途径的≥1个特征来定义。危险因素和分娩方式不包括在内。早产表型有 5 个组成部分：(1) 分娩前出现的母体状况，(2) 分娩前出现的胎儿状况，(3) 胎盘病理状况，(4) 分娩开始的迹象，(5) 分娩途径。该系统不会将任何早产强行归入预设的表型，并允许所有相关情况成为表型的一部分。需要的数据可以从病历中收集，以对每一例早产进行分类。该分类系统将有助于提高对病因的认识，并改善人群监测。
