Baxter BioScience, Vaccine Research and Development, Biomedical Research Centre, Uferstrasse 15, A-2304 Orth a.d. Donau, Austria.
Vaccine. 2012 Feb 1;30(6):1165-9. doi: 10.1016/j.vaccine.2011.12.013. Epub 2011 Dec 14.
Tick-borne encephalitis virus (TBEV) is a flavivirus of wide geographic distribution and the causative agent of tick-borne encephalitis (TBE), an infection of the central nervous system. TBE has the highest incidence rate in Russia, where locally produced as well as Western European vaccines for the prevention of TBE are available. The Western European vaccines are based on TBE viruses that belong to the European subtype, while the Russian vaccines are based on Far Eastern subtype viruses. The question of to which extent vaccination with a vaccine based on the European subtype is effective in protecting against the heterologous Far Eastern virus subtype - and vice versa - has not been answered conclusively. Here we immunized mice with TBE vaccines based on European and Far Eastern subtype viruses, and used an unbiased hybrid virus test system to determine cross-neutralizing antibody titers and cross-protective efficacy. All vaccines tested elicited cross-protective responses against the heterologous strains, similar to those induced against the respective homologous vaccine strains. These data, therefore, fully support the use of TBE vaccines in geographic regions where virus subtypes heterologous to the vaccine strains are prevalent.
蜱传脑炎病毒（TBEV）是一种广泛分布的黄病毒，也是蜱传脑炎（TBE）的病原体，这是一种中枢神经系统感染。俄罗斯的 TBE 发病率最高，那里有当地生产的以及用于预防 TBE 的西欧疫苗。西欧疫苗基于属于欧洲亚型的 TBE 病毒，而俄罗斯疫苗则基于远东亚型病毒。用基于欧洲亚型的疫苗接种在多大程度上能有效预防异源的远东病毒亚型，反之亦然，这个问题尚未得出明确的结论。在这里，我们用基于欧洲和远东亚型病毒的 TBE 疫苗对小鼠进行免疫，并使用一种无偏杂交病毒检测系统来确定交叉中和抗体滴度和交叉保护效力。所有测试的疫苗都对异源株产生了交叉保护反应，与针对相应同源疫苗株产生的反应相似。因此，这些数据完全支持在流行与疫苗株不同的病毒亚型的地理区域使用 TBE 疫苗。
