Alaya A, Nouri A, Belgith M, Saad H, Hell I, Hellara W, Jouini R, Najjar M F
Departamento de Bioquímica y Toxicología, Hospital Universitario, Monastir, Túnez. akram
Actas Urol Esp. 2012 Mar;36(3):171-7. doi: 10.1016/j.acuro.2011.07.019. Epub 2011 Dec 16.
Studies that evaluate the effect of age and gender on the stone composition are scarce. The aim of this study is to highlight the modification of epidemiological characteristics of this pathology according to patients' sex and age.
We studied 1269 urolithiasic patients ranging from 6 months to 92 years old and known as having urinary stones (752 males and 517 females). Stone analysis was performed respectively using a stereomicroscope and infrared spectroscopy to determine, respectively, the morphological type and molecular composition of each.
The annual average incidence of new stone formation was 30.25 per 100,000 inhabitants. In 1041 patients (81%), calculi were located in the upper urinary tract. Children and old man were more affected by bladder stone. Calcium oxalate monohydrate remains the most frequent stone component even if its frequency fell according to age (63.2% in teenagers and 40.6% in elderly [p<0.05]) in favour of the increase of uric acid stones (3,5% in teenagers and 41.5% in elderly [p<0.05]). Struvite stones were rare (3.5%) and more frequent in children.
The analysis of these data shows that urinary stones in Tunisia are tending to evolve in the same direction as in industrialized countries.
评估年龄和性别对结石成分影响的研究很少。本研究的目的是强调根据患者性别和年龄,这种病理的流行病学特征的变化。
我们研究了1269例年龄在6个月至92岁之间的尿路结石患者,这些患者均已知患有尿结石(男性752例,女性517例)。分别使用体视显微镜和红外光谱进行结石分析,以确定每种结石的形态类型和分子组成。
新结石形成的年平均发病率为每10万居民30.25例。1041例患者(81%)的结石位于上尿路。儿童和老年人更容易患膀胱结石。即使一水草酸钙的频率随年龄下降(青少年中为63.2%,老年人中为40.6%[p<0.05]),有利于尿酸结石的增加(青少年中为3.5%,老年人中为41.5%[p<0.05]),但一水草酸钙仍是最常见的结石成分。磷酸铵镁结石很少见(3.5%),在儿童中更常见。
对这些数据的分析表明,突尼斯的尿路结石发展趋势与工业化国家相同。